86 articles - From Friday Aug 26 2022 to Friday Sep 02 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Gastroenterology |
AGA Clinical Practice Update on the Endoscopic Approach to Recurrent Acute and Chronic Pancreatitis: Expert Review. BEST PRACTICE ADVICE 8: Celiac plexus block should not be routinely performed for the management of pain due to chronic pancreatitis. The decision to proceed with celiac plexus block in selected patients with debilitating pain in whom other therapeutic measures have failed can be considered on a case-by-case basis, but only after discussion of the unclear outcomes of this intervention and its procedural risks. |
| Gastrointest Endosc |
Pediatric Endoscopy Quality Improvement Network (PEnQuIN) quality standards and indicators for pediatric endoscopy: an ASGE-endorsed guideline. The PEnQuIN guidelines establish international agreement on clinically meaningful metrics tailored to pediatric endoscopy that can be used to promote safe, high-quality, patient- and family-centered endoscopic care. Moving forward, it is recommended that al providers and facilities involved in endoscopy service for children adopt the PEnQuIN standards, indicators, and key reporting elements outlined in these ASGE-endorsed guidelines. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
Meta-analysis: diagnostic accuracy of hepatitis C core antigen detection during therapy with direct-acting antivirals. The HCVcAg assay may be helpful for monitoring the efficacy of HCV treatment with DAAs in HCV-infected patients at EOT and for documenting SVR, but not at weeks 2 and 4 of treatment due to poor diagnostic performance. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease: Results from the IMmunogenicity to Second Anti-TNF therapy (IMSAT) therapeutic drug monitoring study. Irrespective of drug sequence, immunogenicity to the first anti-TNF agent was associated with immunogenicity to the second anti-TNF, which was mitigated by the introduction of an immunomodulator in patients with immunogenic, but not pharmacodynamic treatment failure. |
The safety of paternal and maternal use of 5-aminosalicylic acid during conception and pregnancy: A nationwide cohort study. Paternal and maternal use of 5-ASA was safe across offspring outcomes; none of the findings reached statistical significance. The safety of 5-ASA formulations that are used infrequently cannot be settled here. |
| Am J Gastroenterol |
Early life mebendazole exposure increases the risk of adult-onset ulcerative colitis: a population-based cohort study. Early life mebendazole exposure is associated with increase in the risk of adult-onset UC. These findings suggest the importance of early life exposures in shaping the risk of IBD later in life. |
| Clin Gastroenterol Hepatol |
Detecting Early Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Using Longitudinal Alpha-fetoprotein Screening. The longitudinal assessment of AFP by the PEB algorithm improved the HCC screening performance compared to AFP alone. This algorithm may improve HCC screening without additional cost or inconvenience to patients. |
Impact of artificial intelligence on colonoscopy surveillance after polyp removal: A pooled analysis of randomized trials. The use of AI during colonoscopy increased the proportion of patients requiring intensive colonoscopy surveillance by approximately 35% in the US and 20% in Europe (absolute increase 2.9% and 1.3%, respectively). While this may contribute to improved cancer prevention, it significantly adds patient burden and healthcare costs. |
MULTICENTER COHORT STUDY OF INFLIXIMAB PHARMACOKINETICS AND THERAPY RESPONSE IN PEDIATRIC ACUTE SEVERE ULCERATIVE COLITIS. At median higher-than-label IFX dosing for pediatric ASUC, baseline faster IFX CL was associated with colectomy and, at week 26, with lack of CSF-CR. IFX exposure was not predictive of clinical outcomes. Higher IFX dosing may sufficiently optimize early outcomes in pediatric ASUC. Larger studies are warranted to determine if sustained intensification can overcome rapid clearance and improve later outcomes. |
National Experience on Waitlist Outcomes for Down-staging of Hepatocellular Carcinoma: High Dropout Rate in "All-Comers". Results The 2-year cumulative probabilities of dropout were 19% for Milan, 25% for UNOS-DS (p 50% 2-year probability of dropout. These observations suggest a high likelihood of failure when expanding the indications for down-staging. |
Predictors of Placebo Induction Response and Remission in Ulcerative Colitis. Biomarkers such as normal serum CRP and albumin and baseline endoscopic severity were found to affect placebo response rates in clinical trials of UC. These findings have implications for clinical trial design in UC. |
The role of off-therapy viral kinetics in the timing and severity of flares in hepatitis B e antigen-negative patients. Methods HBeAg-negative chronic hepatitis B (CHB) patients who developed off-ETV or off-TDF hepatitis flare were recruited. Their HBV kinetics and the severity of flares were compared between patients with early ( IU/mL in early off-TDF flare is important for timely retreatment to prevent decompensation. |
| Endoscopy |
A root cause analysis system to establish the most plausible explanation for post-endoscopy upper gastrointestinal cancer. CONCLUSION : Missed opportunities to avoid PEUGIC were identified in 71 |
Endoscopic ultrasound-guided fine-needle biopsy with or without macroscopic on-site evaluation: a randomized controlled noninferiority trial. CONCLUSIONS : The accuracy of EUS-FNB with MOSE is noninferior to that of EUS-FNB with three needle passes. MOSE reliably assesses sample adequacy and reduces the number of needle passes required to obtain the diagnosis with a 22G Franseen needle. |
| Gastroenterology |
Intestinal ultrasound is accurate to determine endoscopic response and remission in patients with moderate to severe ulcerative colitis: a longitudinal prospective cohort study. IUS, importantly BWT as the single most important parameter, is highly accurate to detect treatment response when evaluated against endoscopic outcomes. |
| Gastrointest Endosc |
Development of ileal adenomas after ileal pouch-anal anastomosis versus end ileostomy in patients with familial adenomatous polyposis. After proctocolectomy, FAP patients with IPAA more often developed ileal adenomas than patients with end ileostomy. This could potentially affect long-term management and patients with end ileostomy might benefit from less frequent endoscopic surveillance. |
Identification of patients with malignant biliary strictures using a cholangioscopy-based deep learning artificial intelligence (with video). This study demonstrates that a CNN developed using cholangioscopy data alone has greater accuracy for biliary stricture classification than traditional ERCP-based sampling techniques. |
Identification of Visible Lesions During Surveillance Endoscopy for Barrett's Esophagus: A Video-Based Survey Study. Despite improved endoscope resolution and availability of virtual chromoendoscopy, the overall rate of VL detection remains low. Identification of VLs using NBI may be volume dependent. Further education and training efforts focused on VL detection during Barrett's surveillance endoscopy are needed. |
NICE-derived, high confidence optical diagnosis of small polyps compared to histology: understanding errors to improve diagnostic accuracy. Optical diagnosis errors can be related to endoscopist-related factors such as poor photodocumentation, failures of current classification systems and incomplete histology. We identified a subset of serrated polyps frequently misdiagnosed as adenomas ("pseudoadenomas") using the NICE classification. An enhanced algorithm for optical diagnosis is proposed based on the NICE classification including morphological and adjunct polyp features. |
Scheduled endoscopic treatment of biliary anastomotic and non-anastomotic strictures after orthotopic liver transplantation. Scheduled endoscopic treatment of biliary anastomotic and non-anastomotic strictures after liver transplantation is effective and safe, with high success rates. The implementation of this strategy controls symptoms and significantly improves the survival. |
Second-Generation Distal Attachment Cuff for Adenoma Detection in Screening Colonoscopy: A Randomized Multicenter Study. A distal attachment cap with side arms significantly increases ADR also in patients undergoing primary colonoscopic screening. Due to the correlation of ADR and interval cancer, its use should be encouraged especially in this setting. |
| Gut |
Distinct blood protein profiles associated with the risk of short-term and mid/long-term clinical relapse in patients with Crohn's disease stopping infliximab: when the remission state hides different types of residual disease activity. We identified distinct blood protein profiles associated with the risk of short-term and mid/long-term clinical relapse in patients with CD stopping infliximab. These findings constitute an advance for the development of non-invasive biomarkers guiding the decision of anti-TNFa withdrawal. |
Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity. Exposure of rodents to human gut microbiota after restrictive or malabsorptive bariatric surgery improves glycaemic control. The gut microbiota after bariatric surgery is a standalone factor that alters upper gut intestinal morphology and lowers Sglt1-mediated intestinal glucose absorption, which improves blood glucose control independently from changes in obesity, insulin or insulin resistance. |
| Hepatology |
Natural History of Liver Disease in a Large International Cohort of Children with Alagille syndrome: Results from The GALA Study. In this large international cohort of ALGS, only 40.3% of children reach adulthood with their native liver. A TB <5.0 mg/dL between 6-and-12-months of age is associated with better hepatic outcomes. These thresholds provide clinicians with an objective tool to assist with clinical decision-making and in the evaluation of novel therapies. |
| J Hepatol |
Long-term persistence of HCV resistance-associated substitutions after DAA treatment failure. We found that low to medium-level RASs persisted, while high-level resistant RAS disappeared over time. Different patterns of RAS persistence according to HCV subtype could have implications for retreatment with first generation DAAs and for global HCV elimination goals. |
Validation of Baveno VII criteria for recompensation in entecavir-treated individuals with hepatitis B-related decompensated cirrhosis. Our study defined the criteria for a stable improvement of liver function tests required by the Baveno VII definition of recompensation in patients with CHB-related decompensated cirrhosis on antiviral therapy. The criteria derived from this multicentre prospective study warrant further validation in patients with cirrhosis of other aetiologies. |
| Neurogastroenterol Motil |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Hepatology |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Am J Gastroenterol |
| Hepatology |
| J Hepatol |